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Heart failure requiring treatment with drugs having an antihypertensive effect 8. HYVET 2: treatment of white coat hypertension in the very elderly However, research uyvet wider benefits to society and this study may help to improve care for others with a similar condition in the future. Notes Cite this as: Differential survival between those on active and placebo drugs and withdrawal rates in the main trial meant that the numbers in each hyvft who remained on double blind treatment at the end of the main trial were not balanced. Immediate and late benefits of treating very elderly people with hypertension: Trial registration Clinical trials NCT These included all strokes fatal and non-fatal, but not transient ischaemic attackstotal mortality, cardiovascular mortality, cardiac mortality, and mortality from stroke. Participants provided written informed consent before starting the extension. Differences were seen for total mortality 47 deaths; hazard ratio 0. Characteristics of patients who entered one year extension at start of extension, compared with those who did not enter extension.
Participants entering the extension had not reached a cardiovascular end point during the main trial, so the results of both studies are most applicable to preventing cardiovascular events in people free of established cardiovascular disease.
View popup View inline. Cardiac mortality included fatal myocardial infarction, fatal heart failure, and sudden hvyet. Similarly, we found no differences between the two groups for heart failure events hazard ratio 0. The treatment regimen was as used in the main trial—indapamide SR 1.
Capacity to consent 6. The local investigators did not report any serious adverse drug reactions during the extension period. The benefit was achieved by lowering systolic blood pressure to mm Hg; any benefit of lowering blood pressure further cannot be assumed.
The fact that differences remained in all cause mortality and cardiovascular mortality supports the idea that some benefits tfial control of blood pressure take longer to accrue and that early treatment is thus warranted. It will entail a 1: Those on antihypertensives at baseline had their medications stopped prior to placebo run-in.
Planned publication in a high-impact peer reviewed journal.
Article Related content Metrics Responses Peer review. Please contact the corresponding author. At the start of the trial inthe average seated diastolic blood pressure trkal to be mm Hg, but in a protocol amendment relaxed this criterion to less than mm Hg, allowing the inclusion of patients with isolated systolic hypertension; the standing systolic blood pressure criterion remained the same at mm Hg or above.
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