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Keywords: Heliopsis longipes, affinin, vasodilation, rat aorta, Available online : Bauer R. Heliopsis longipes S.F. Blake (Asteraceae) is a perennial herb endemic to Sierra Gorda and Sierra Alvarez, a moun- tainous region located in. ABSTRACT. Heliopsis longipes is a popular medicinal plant in Mexico. One of the main constituents that can be extracted from H. longipes is affinin.

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PDF | Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. PDF | Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and . Heliopsis longipes (A. Gray) Blake (Asteraceae) is a species broadly used in Mexican Traditional Medicine. The present study illustrates the.

Velez-Haro, Nydia E. However, the effect on Aspergillus parasiticus has not been investigated so far. This study was aimed to evaluate the antifungal effect of the ethanolic extract from H. All tested concentrations inhibit the radial growth of A. These results showed the first evidence of the antifungal effect of H. The antifungal activity of H.

Gokhale and B. Bhide, J.

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Indian Chem. Pendse, et al. Bombay, 1 6 8 , N. Gersdor5 and N. The 3,5-dinitrobenzoate crystallized from ethanol in colorless needles, m. Food and Drug Administration. Reichstein, C. Amman and G. Trivelli, Helu. After addition was complete 1 hour , the mixture was stirred at room temperature for 3 hours; t h e liquid was then decanted off, and the semi-solid layer was washed by decantation with two small portions of ether, which was added to the liquid layer.

T h e solution was freed of solvent under reduced pressure, and the residue was distilled, giving, after a small forerun b. Found: C, Diethyl Sorbylmalonate IV. The solution of sodium ethylate was cooled to SO", and The solution turned cloudy, a white solid separated, and the temperature of the mixture rose gradually t o 76'.

After addition was complete 0. After separation of the layers, the aqueous layer was mashed with several small portions of ether, and the combined ether solutions were washed with water, T.

Removal of solvent and distillation of the residue gave the desired product Sorbylmalonic Acid V. The acid solution was extracted with three ml. Removal of the solrelit left a white crystalline cake, which was recrystallized from benzene-petroleum ether b. For CeHln C, The solution was extracted once with ether to remove neutral materials, then acidified to congo red with , hydrochloric acid solution and extracted with three ml.

The combined ether solution was washed with water, dried over sodium sulfate, and freed of solvent.

Pdf heliopsis longipes

The acid was very thermostable, IIO dccotnposition occurring even on heating to '. T h e solution was allowed to stand overnight at room temperature, and was then refluxed on t h e steamh a t h for one hour. After removal of the solvent and excess thioiiyl chloride under redliceti pressure, the resi l1ir was tiistilled to give 5.

Distillation of the residue yielded 5. The substance was iieither pungent nor toxic t o adult house flies. Ltrhen addition was complete 2 hours , the mixture was cooled in an ice-bath arid water was carefully added, followed by ml. The separated ether layer mas washed with water and dried over sodium sulfate.

Removal of the solvent and distillation of the residue gave Found: C , The 3,5-dinitrobe,izoate crystallized from ethanol as cream-colored needles, in. On reduction with platinum oxide cdtal? A pure sample of I-octanol showed b.

In 12 minutes the mixture had turned green and it was extracted with three ml.

Constituents of Heliopsis Species. IV. The Total Synthesis of trans

All-txns-2,6,8-decatrienoic Acid IX. S o solid formation was noted.

Longipes pdf heliopsis

The mixture was allowed to stand at room temperature for 72 hours, and then heated on the steam-bath for 8 hours. The solution was poured into ml. This alkaline solutioii was extracted with a small portion of ether and then madc acid t o congo rcti with cold h!.

The acid soliltion was extracted with ether, and the extract was then dried over sodium sulfate. Evaporation of t h e solvent left an oily solid, which was recrystallized from petroleum ether b.

The white solid remaining was recrystallized twice from petroleum ether h. Found: c , The oxidation of 2-naphthol has been the subject of a number of investigations.

Generally, mild oxidizing agents lead to the formation of such compounds as binaphthols and binaphthylene oxides, etc.

Heliopsis longipes

This seems to be the only case of the actual isolation of a quinone from the oxidation of 2-naphthol, although unidentifiable materials sometimes have been obtained. This investigation was undertaken to study the oxidation of 2-naphthol in the presence of sodium hydroxide. On exposure to air, solutions of 2naphthol in aqueous sodium hydroxide darken on standing.

Keywords: Heliopsis longipes, affinin, vasodilation, rat aorta, gasotransmitters, prostacyclin 1. Introduction Heliopsis longipes A.

Get PDF - Purely olefinic alkamides in Heliopsis longipes and Acmella (Spilanthes) oppositifolia

Gray S. Blake Asteraceae H. In Central Mexico, the roots of this species are widely used as a spice, home insecticide, and for the treatment of some illnesses, which include toothaches, gingival disease, and muscular pain [ 5 , 6 , 7 , 8 ].

When H. The predominant bioactive molecules found in H.

This alkamide is not only found in H. Some of these pharmacological activities have been also reported for crude organic extracts of H.

Affinin has an adequate lipophilicity.

Longipes pdf heliopsis

Therefore, this compound might be considered a valuable potential drug candidate [ 13 , 18 , 23 , 33 ]. No cytotoxic effects of affinin, which elicits a stimulatory effect on nitric oxide NO production in RAW It has been well documented that this signaling pathway plays an important role in vascular tone regulation [ 34 , 35 , 36 , 37 , 38 , 39 ]. This physiological process is also regulated by other gasotransmitters, such as hydrogen sulfide H2S and carbon monoxide CO [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].

Longipes pdf heliopsis

Together with gasotransmitters, vascular endothelium releases prostacyclin, which also represents a key piece in the vasodilation process [ 55 , 56 , 57 ].