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So when he gets a call from Essex police, he's eager for the chance to assist them. A badly decomposed body has been found in a desolate area of tidal mudflats and saltmarsh called the Backwaters. Under pressure to close the case, the police want Hunter to help with the recovery and identification. It's thought the remains are those of Leo Villiers, the son of a prominent businessman who vanished weeks ago. To complicate matters, it was rumoured that Villiers was having an affair with a local woman.

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Structural MRI measures, for instance, are useful not only for measuring brain atrophy Frisoni et al. Multivariate methods can also combine multiple biomarkers to select subjects more likely to show detectable change in hypothetical AD trials Kohannim et al.

ApoE is the greatest known genetic risk factor for late-onset AD Bertram et al. Even so, ApoE does not account for all of the inherited risk for AD.

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As other risk genes are discovered and validated, genotyping should even further reduce sample size requirements. Since then, several studies, including meta-analyses, have replicated these findings in large cohorts of healthy controls and pathologically confirmed, late-onset AD patients Carrasquillo et al.

Most recently, Ferrari et al.

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Here, we assessed how the 3 recently discovered AD risk genes i. We hypothesized that a genetic score derived from these top AD risk genes would enrich a hypothetical 2-year clinical trial beyond just selecting ApoE4 carriers. We focused on MCI and healthy controls, similarly to prior enrichment studies Lorenzi et al.

Methods 2.

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